01635nas a2200181   4500008004100000245011000041210006900151300001100220490000600231520103600237100002101273700001901294700002001313700002101333700002201354700002201376856005501398       2022                        eng d00aThe long-tail effect of the COVID-19 lockdown on Italians’ quality of life, sleep and physical activity0 alongtail effect of the COVID19 lockdown on Italians quality of l  a1–100 v93 aFrom March 2020 to May 2021, several lockdown periods caused by the COVID-19 pandemic have limited people’s usual activities and mobility in Italy, as well as around the world. These unprecedented confinement measures dramatically modified citizens’ daily lifestyles and behaviours. However, with the advent of summer 2021 and thanks to the vaccination campaign that significantly prevents serious illness and death, and reduces the risk of contagion, all the Italian regions finally returned to regular behaviours and routines. Anyhow, it is unclear if there is a long-tail effect on people’s quality of life, sleep- and physical activity-related behaviours. Thanks to the dataset described in this paper, it will be possible to obtain accurate insights of the changes induced by the lockdown period in the Italians’ health that will permit to provide practical suggestions at local, regional, and state institutions and companies to improve infrastructures and services that could be beneficial to Italians’ well being.1 aNatilli, Michela1 aRossi, Alessio1 aTrecroci, Athos1 aCavaggioni, Luca1 aMerati, Giampiero1 aFormenti, Damiano  uhttps://www.nature.com/articles/s41597-022-01376-5